Overdose

When xylazine is taken in combination with opioids such as fentanyl, it increases the risk of a life-threatening overdose.

Most overdose deaths related to both xylazine and fentanyl also involve additional substances, such as cocaine, benzodiazepines, alcohol, methadone, and prescription opioids.

Testing drugs before using them can help reduce the risks of xylazine and overdose.

Alcohol