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How does Kratom Affect the Body?

Kratom is not approved by the FDA and is not regulated under the Controlled Substances Act. The DEA labels kratom as a "Drug of Chemical Concern".

Despite reports of milder withdrawal symptoms compared to opioids, kratom use can lead to physiological and psychological dependence. Kratom can be addictive. Individuals seeking treatment can call the 24/7 Access Line at 1.800.563.4086. 


  • At low doses, kratom is associated with stimulant-like effects. In small amounts, it is reported to produce higher levels of energy, alertness, and increased heart rate. 
  • At high doses, kratom is associated with effects similar to that of opioids and sedatives. In large amounts, it is reported to produce feelings of relaxation, pain relief, and confusion.
  • While these effects are reported to be associated with kratom dosage, research has yet to confirm that these effects are connected to the amount consumed or method of consumption.

Impact on the body:

    • Nausea
    • Vomiting
    • Loss of appetite
    • Dry mouth
    • Constipation
    • Increased Urination
    • Dizziness
    • Drowsiness
    • Itching

    • Agitation
    • Confusion
    • Tremors
    • Seizures

  • High blood pressure
  • Slow or suppressed breathing
  • Increased heart rate (tachycardia)

    • Weight loss
    • Anorexia
    • Insomnia
    • Hallucinations
    • Liver damage/reduced liver function (hepatotoxicity)
    • Death

Source: NIDA, DEA, PMC

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